CTB-02 is a patented combination use of targeted drugs for the treatment of BRAF/KRAS mutant colon cancer and KRAS mutant non-small cell lung cancer. The application for a clinical trial for BRAF mutant colon cancer has been approved in Australia.
Marketed drugs have been combined into “cocktail therapy”
- i-CR® platform facilitates the selection process of various drugs and drug combinations.
- Flexible criteria for picking the best combinations: e.g. prioritizing the drugs with expiring patents on top of creating the safest and most effective combinations./li>
Screening for biomarkers to find the patients with the right indications, presenting a huge market space
- BRAF mutations account for 8-12% of colon cancer
- KRAS mutations account for 35-45% of colon cancer
- KRAS mutations account for 15-25% of non-small cell lung cancer
CTB-02 displays striking efficacy in the PDX models of BRAF-mutant colon cancer, as well as satisfactory animal tolerance.
CTB-02 shows useful anti-tumor effects in various KRAS mutant NSCLC models.
The clinical trial is starting soon.
- The clinical trial was cleared in Australia in September 2019.
- The Australian clinical research team, clinical medical center, and laboratory are already in place.